Intermittent Fasting & Supplements: What to Take When
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Two of the most data-obsessed voices in longevity — Rhonda Patrick and Andrew Huberman — have both spent significant time on fasting. Here's the pharmacist synthesis you can actually use.
Time-Restricted Eating (TRE): Huberman's Framework
Compress your eating window to 6–10 hours, beginning 1–2 hours after waking and ending 2–3 hours before sleep. Benefits include improved insulin sensitivity, better sleep quality, enhanced fat oxidation, and reduced inflammation. An 8-hour window — roughly noon to 8pm — is where most people start.
Fasting-Mimicking Diet (FMD): Rhonda's Deep Dive
Valter Longo's 5-day protocol (~700–1,100 kcal/day, low-protein, high-fat) triggers autophagy and cellular cleanup without full water fasting. Clinical trial results: autophagy activation, IGF-1 reduction, stem cell regeneration post-refeed, and improved metabolic markers. 2–4 cycles per year is what the research supports.
Supplement Timing During Fasting — The Pharmacist Guide
- Vitamin D + K2 Liquid by Thorne — fat-soluble, take with your first meal. Not fasted.
- Magnesium Bisglycinate by Thorne — fine to take fasted, especially helpful at night for sleep.
- Creatine by Thorne — timing relative to fasting is irrelevant. Take it whenever.
- Basic B Complex by Thorne — best with food to avoid nausea.
- Super EPA by Thorne — take with your largest meal for best absorption.
Tampa Fasting Reality
Fasting in Florida heat is a different animal. Dehydration happens faster. Electrolyte losses through sweat are real. If you're doing TRE during Tampa summer, prioritize sodium, potassium, and magnesium replenishment in your eating window.
Talk to us at VitaScripts Pharmacy about integrating fasting with any medications. Browse vuzzy.com.
Educational only. Fasting is not appropriate for everyone — consult your healthcare provider.